Coenzyme Q10 Metabolism Benefits

Adenosine triphosphate (ATP) is our energy currency, and coenzyme Q10 is actively used by our body to produce this ATP, this energy. So, what’s the deal here? This coenzyme is found in almost all the tissues of our body in the form of a phenol called ubiquinone. Now, I’ll explain the difference because people often confuse coenzyme Q10 in the forms of ubiquinone and ubiquinol. They sound similar, but there is a difference, and I’ll tell you all about it.

Coenzyme Q10 helps in the energy metabolism to produce ATP under aerobic conditions. This is very important under aerobic conditions or the synthesis of ATP. Here’s another role where I directly refer to the various schemes for energy supply of our muscles. What is this? First and foremost for us, it’s aerobic oxidation, aerobic ATP production. This is not just exercising on a treadmill, but our everyday life. For instance, when you write with a pen, that’s cellular respiration. When you sleep, your cells’ mitochondria burn fatty acids, which is also cellular respiration. They burn glucose to get ATP using oxygen. When you simply walk, that’s also aerobic glycolysis or aerobic oxidation – it’s cellular respiration. And in all these processes that constantly happen 24/7, 365 days a year, this very coenzyme Q10 is involved, which I now show you as a supplement.

This stuff is indeed very important, as you can understand. If we have oxidation, that’s part of the cellular respiration process. This all happens where? Right, in the energy stations of our cells – the mitochondria. Therefore, the highest amount of this coenzyme, which is necessary for this activity, is in the heart muscle, the myocardium. Yes, exactly, in the heart muscle, because it works continuously, is rich in mitochondria, and constantly needs this coenzyme.

Why is this substance considered vitamin-like and not classified as a vitamin? For one simple reason – it is synthesized inside our body. It’s so important that our body can’t do without it. When a person is young and lives in nature with proper nutrition, usually there is no shortage of this coenzyme Q10. However, with age or various diseases, especially with the intake of statins, or diseases like asthma and diabetes, the concentration of this coenzyme Q10 decreases. In a 60-year-old person, the concentration of coenzyme Q10 might be around 40% less than normal. If it drops to 25%, it’s already a precursor to serious diseases. If it’s 50% or 75%, it’s incompatible with life. So, you see how important this stuff is.

With age or if we live in large cities with many free radicals (which I’ll talk about shortly), the concentration of coenzyme Q10 drops, and our heart muscle suffers the most. The myocardium, which works constantly, regardless of whether we want to exercise or not, keeps beating and requires constant ATP resynthesis through cellular respiration.

That’s why older people should think about the future. Considering that I experience significant physical strain and train quite intensively for my age, it’s advisable for me to take this supplement.

Free radicals can damage molecules by taking electrons from them, damaging cell membranes and even DNA, leading to aging due to accumulated errors. Coenzyme Q10 acts as an antioxidant, especially where free radicals are most harmful, such as in the heart muscle.

We have two forms of coenzyme Q10: ubiquinone and ubiquinol. Don’t confuse them. Ubiquinol is the reduced form of ubiquinone, with a hydrogen molecule added, giving it maximum antioxidant potential. The only downside is the cost. More research has been done on ubiquinone, and the Nobel Prize was awarded for research on ubiquinone, not ubiquinol. So, I traditionally use coenzyme Q10 in the form of ubiquinone, although ubiquinol is more bioavailable.

CoQ10 Key Benefits for Specific Populations and Conditions

CoQ10 supplementation may be beneficial for certain groups of people and under specific conditions:

1. Ageing Population: As people age, natural levels of CoQ10 in the body tend to decrease. Supplementing can help replenish these levels.
2. Patients with Heart Conditions: Individuals with congestive heart failure, angina, or high blood pressure might benefit from CoQ10, as it supports cardiovascular health.
3. Statin Users: Some cholesterol-lowering medications (statins) can reduce the natural levels of CoQ10 in the body. Those on statin therapy might consider CoQ10 supplementation to counteract this effect. For example, David Sinclair, a prominent longevity scientist, takes CoQ10 in conjunction with his daily statin prescription, as statins can deplete the body’s natural CoQ10 levels.
4. Mitochondrial Disorders: Since CoQ10 plays a role in energy production within the mitochondria, individuals with mitochondrial disorders might benefit from its supplementation.
5. Neurological Disorders: Preliminary research suggests that CoQ10 might be beneficial for conditions like Parkinson’s disease, although more research is needed.
6. Athletes and Active Individuals: Some believe that CoQ10 can help improve exercise performance by increasing energy production, though evidence is mixed.

CoQ10 Deficiency, Potential Indicators and the Importance of Balance

While a clear deficiency syndrome for CoQ10 has not been identified, some potential symptoms and signs might suggest a need for more CoQ10:

1. Muscle Weakness and Fatigue: Since CoQ10 is involved in energy production, a deficiency might lead to feelings of tiredness or physical weakness.
2. High Blood Pressure: CoQ10 has been linked to optimal blood pressure levels.
3. Cognitive Dysfunction: Reduced levels of CoQ10 might impact cognitive health, leading to difficulty concentrating or memory issues.
4. Vision Problems: Some eye conditions, like age-related macular degeneration, have been linked to lower CoQ10 levels.
5. Hearing Disorders: There’s some evidence to suggest that CoQ10 deficiency might be linked to certain hearing conditions.
6. Migraines: Some studies suggest that CoQ10 supplementation can reduce the frequency of migraines, implying a potential link between migraines and CoQ10 levels.

When to Start CoQ10: Age Guidelines and Health Considerations

The decision to start taking CoQ10 supplements can depend on various factors, including age, health conditions, and individual needs. Here’s what some sources suggest regarding the age to start taking CoQ10:

1. Natalist mentions that CoQ10 is safe for most people after the age of 18 and is encouraged for anyone with mitochondrial issues.
2. Boston Heart suggests that individuals over the age of 50 take at least 100 mg of CoQ10 supplement per day.
3. Life Extension states that coenzyme Q10 levels start to decline in important organs such as the heart around age 26 and in the skin around age 30.
4. An article suggests that women in their 40s should consider taking CoQ10 as it can help reduce the occurrence of heart conditions.
5. Better Nutrition recommends that people start taking 30-50 mg daily of CoQ10 in their mid-30s.
6. Healthline mentions that for those concerned about age-related depletion of CoQ10, it’s recommended to take 100-200 mg per day.

Do Healthy Lifestyles Require CoQ10 Supplementation?

Whether or not you need CoQ10 supplements while maintaining a healthy diet, taking vitamins, and exercising regularly depends on various factors. Here’s what some sources suggest:

1. WebMD states that CoQ10 can be found in many foods, but dietary sources typically contain much less CoQ10 than supplements. For some individuals, a combination of supplements and a healthy diet may be beneficial.
2. The Office of Dietary Supplements mentions that performance supplements cannot substitute for a healthy diet. This implies that while a healthy diet is essential, certain supplements might offer additional benefits for those who exercise regularly or are athletes.
3. Healthline notes that CoQ10 is used to treat various health conditions and can be obtained through foods like eggs and fatty fish. However, the amount in these foods might not be sufficient for therapeutic purposes.
4. Mount Sinai suggests that taking CoQ10 supplements can bring levels back to normal in individuals who might have a deficiency.

While CoQ10 is naturally present in some foods, the amounts might not be enough to meet the body’s needs, especially if there’s an underlying condition or increased demand. However, if you maintain a balanced diet, get essential nutrients from food, and have no specific health concerns related to CoQ10 levels, supplementation might not be necessary.

CoQ10 in the Bloodstream: Leading Labs and Their Diagnostic Offerings

There are blood tests available to measure CoQ10 levels in the body. Here are some details and sources that offer the CoQ10 blood test:

1. Labcorp provides a test for Coenzyme Q10, Total. This test measures the total amount of CoQ10 in the blood.
2. Walk-In Lab offers a Coenzyme Q10 Blood Test that measures coenzyme levels, which help in digestion and other body processes, and also play a role in protecting the heart and skeletal muscles.
3. Life Extension has a CoQ10 blood test that measures blood levels of the antioxidant CoQ10, which is essential for energy production in cells.
4. SelfDecode mentions that the normal range for blood CoQ10 levels usually lies between 0.4 – 1.9 mg/L (or μg/mL), but this can vary between labs.
5. HealthMatters.io provides information on Coenzyme Q10 levels and states that the optimal result is between 0.48 – 3.04 mg/L.
6. Personalabs offers a Coenzyme Q10 Blood Test and mentions that CoQ10 blood levels are reported to decrease with age and can be low in individuals with certain chronic diseases.
7. Ulta Lab Tests provides a test for Coenzyme Q10 (CoQ10) that measures the level of Coenzyme Q10 in the blood.

CoQ10 Dosage, Timing, and Best Practices

Here’s a general overview of CoQ10 dosage, regimen, and recommendations on what to take it with:

Dosage:

• The standard dosage for CoQ10 typically ranges between 60 and 500 milligrams daily.
• For specific health conditions or therapeutic purposes, dosages might be adjusted, with some recommendations going up to 1,200 mg daily.

Regimen:

• CoQ10 can be taken once daily or divided into multiple doses throughout the day, depending on the total daily dosage and individual preference.
• It’s often recommended to start with a lower dose and gradually increase if needed, especially if you’re new to the supplement.

To Take With:

• CoQ10 is fat-soluble, so it’s best absorbed when taken with a meal containing healthy fats, such as avocados, nuts, seeds, or olive oil.
• Some people prefer to take CoQ10 with a glass of water or juice to aid in swallowing and digestion.
• If you’re on medications, especially blood thinners or statins, it’s essential to consult with a healthcare provider to ensure there are no interactions.

Treading Carefully with CoQ10 – What You Need to Know

While CoQ10 is generally considered safe for most people, there are potential downsides or side effects to taking CoQ10 supplements. Here are some of the reported side effects and considerations:

1. Mayo Clinic mentions that while CoQ10 supplements appear to be safe, it’s essential to take them under a doctor’s supervision.
2. MedShadow states that CoQ10 supplements can cause nausea, diarrhea, and insomnia, especially at high dosages.
3. Mount Sinai advises that if you are on blood thinners, you should consult with your healthcare provider before taking CoQ10. This is because CoQ10 might interact with certain medications.
4. MedicineNet lists potential side effects of CoQ10 supplements, including the possibility that it might be the wrong dose for a specific condition.
5. NCCIH mentions that mild side effects such as insomnia or digestive upsets may occur. Additionally, CoQ10 may interact with the anticoagulant (blood thinner) warfarin and certain diabetes drugs.
6. Everyday Health lists side effects of CoQ10, including upset stomach, nausea, heartburn, vomiting, loss of appetite, diarrhea, and skin rashes.
7. Healthline warns that while rare, there have been reports of adverse side effects such as serious muscle injury and liver damage associated with CoQ10.

Merging Omega-3 and CoQ10

Taking Omega-3 and CoQ10 together can offer combined health benefits, especially for heart health. Here’s what some sources suggest:

1. Performance Lab mentions that there are endless health benefits to taking omega-3 supplements and CoQ10 together.
2. Cedars-Sinai notes that while both fish oil (Omega-3) and CoQ10 have benefits for heart health, research shows that fish oil supplements can be risky in high doses.
3. Wright Center for Women’s Health states that Omega 3+ CoQ10 promotes normal heart function, blood vessel function, and brain health when taken daily.
4. A study on PubMed explored the addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in subjects with combined dyslipidemia.
5. Thorne offers a product that combines Omega-3 with CoQ10, suggesting that the combination can be beneficial.
6. Livestrong mentions that both CoQ10 and Omega-3 are often consumed individually or together to improve brain and heart health. Some supplements even combine the two compounds.
7. Weight and Wellness emphasizes the importance of Omega-3 and CoQ10 for heart health, noting that both need to be consumed from food or supplements as the body doesn’t produce them in sufficient amounts.

CoQ10’s Potential Role in Alleviating Anxiety

There is some evidence to suggest that CoQ10 may have potential benefits for individuals with anxiety. Here are a couple of sources that discuss the relationship between CoQ10 and anxiety:

1. ChiroEco published an article titled “Don’t worry, be happy: CoQ10 for anxiety and depression”, which suggests that the antioxidant benefits of CoQ10 may help improve symptoms of mood disorders.
2. A study on PubMed explored the antidepressant effects of CoQ10 treatment. The dosage of CoQ10 started at 400 mg daily for two weeks and then was titrated up to a dosage of 800 mg.

Choosing Between CoQ10 and Ubiquinol – Which Reigns Supreme?

While CoQ10 is a popular supplement known for its antioxidant properties and potential benefits for heart health, energy production, and more, there are other supplements and compounds that some consider to be superior or more effective for specific health concerns.

Dr. Neal Smoller provides an in-depth guide comparing CoQ10 vs. Ubiquinol. Ubiquinol is the reduced form of CoQ10 and is often considered more bioavailable, meaning the body might absorb and use it more efficiently.

A study on PubMed titled “Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status” suggests that Ubiquinol might be more effective in enhancing CoQ10 status in the body compared to the standard form of CoQ10, known as ubiquinone.

My CoQ10 Journey – A Blend of Hope and Skepticism

I’ve been incorporating CoQ10 into my wellness routine several times a week, blending it seamlessly with a myriad of other supplements I’ve curated over time. While I’m a firm believer in the power of holistic health, I must admit, I’m still on the fence about the specific impact of CoQ10 on my body. Maybe it’s the scientist in me, always seeking empirical evidence. As the old saying goes, “Patience is a virtue,” so I’m giving it time. In the vast world of supplements, choosing the right one can feel like finding a needle in a haystack.

Here’s my bottle, purchased from iHerb:

Doctor’s Best, High Absorption CoQ10 with BioPerine, 100 mg, 60 Softgels

Serving Size: 1 Softgel
Servings Per Container: 60

Amount Per Serving:
Coenzyme Q10 (Ubiquinone): 100 mg
Black Pepper Extract: 5 mg